Ndiyona is a constituency in the Kavango East region of Namibia. The district centre is the settlement of Ndiyona. It had a population of 20,633 in 2011, up from 19,565 in 2001. As of 2020 the constituency had 6,210 registered voters.
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{"type":"standard","title":"Insulin receptor","displaytitle":"Insulin receptor","namespace":{"id":0,"text":""},"wikibase_item":"Q422579","titles":{"canonical":"Insulin_receptor","normalized":"Insulin receptor","display":"Insulin receptor"},"pageid":604224,"thumbnail":{"source":"https://upload.wikimedia.org/wikipedia/commons/thumb/8/84/IR_Ectodomain_mod3LOH.png/330px-IR_Ectodomain_mod3LOH.png","width":320,"height":307},"originalimage":{"source":"https://upload.wikimedia.org/wikipedia/commons/8/84/IR_Ectodomain_mod3LOH.png","width":736,"height":707},"lang":"en","dir":"ltr","revision":"1288295902","tid":"4f9ed7b9-26bc-11f0-9b0a-90dc851b59bb","timestamp":"2025-05-01T18:44:28Z","description":"Cell receptor found in humans","description_source":"local","content_urls":{"desktop":{"page":"https://en.wikipedia.org/wiki/Insulin_receptor","revisions":"https://en.wikipedia.org/wiki/Insulin_receptor?action=history","edit":"https://en.wikipedia.org/wiki/Insulin_receptor?action=edit","talk":"https://en.wikipedia.org/wiki/Talk:Insulin_receptor"},"mobile":{"page":"https://en.m.wikipedia.org/wiki/Insulin_receptor","revisions":"https://en.m.wikipedia.org/wiki/Special:History/Insulin_receptor","edit":"https://en.m.wikipedia.org/wiki/Insulin_receptor?action=edit","talk":"https://en.m.wikipedia.org/wiki/Talk:Insulin_receptor"}},"extract":"The insulin receptor (IR) is a transmembrane receptor that is activated by insulin, IGF-I, IGF-II and belongs to the large class of receptor tyrosine kinase. Metabolically, the insulin receptor plays a key role in the regulation of glucose homeostasis; a functional process that under degenerate conditions may result in a range of clinical manifestations including diabetes and cancer. Insulin signalling controls access to blood glucose in body cells. When insulin falls, especially in those with high insulin sensitivity, body cells begin only to have access to lipids that do not require transport across the membrane. So, in this way, insulin is the key regulator of fat metabolism as well. Biochemically, the insulin receptor is encoded by a single gene INSR, from which alternate splicing during transcription results in either IR-A or IR-B isoforms. Downstream post-translational events of either isoform result in the formation of a proteolytically cleaved α and β subunit, which upon combination are ultimately capable of homo or hetero-dimerisation to produce the ≈320 kDa disulfide-linked transmembrane insulin receptor.","extract_html":"
The insulin receptor (IR) is a transmembrane receptor that is activated by insulin, IGF-I, IGF-II and belongs to the large class of receptor tyrosine kinase. Metabolically, the insulin receptor plays a key role in the regulation of glucose homeostasis; a functional process that under degenerate conditions may result in a range of clinical manifestations including diabetes and cancer. Insulin signalling controls access to blood glucose in body cells. When insulin falls, especially in those with high insulin sensitivity, body cells begin only to have access to lipids that do not require transport across the membrane. So, in this way, insulin is the key regulator of fat metabolism as well. Biochemically, the insulin receptor is encoded by a single gene INSR, from which alternate splicing during transcription results in either IR-A or IR-B isoforms. Downstream post-translational events of either isoform result in the formation of a proteolytically cleaved α and β subunit, which upon combination are ultimately capable of homo or hetero-dimerisation to produce the ≈320 kDa disulfide-linked transmembrane insulin receptor.
"}